Presented are chemical properties of the antiviral drug Acyclovir, which is also known under its generic name Zovirax. This drug is used for the treatment of sexually transmitted diseases including genital herpes.
It has been nearly quarter of a century since the antiviral drug Acyclovir was first approved and brought into the market as one of the most effective antiviral drugs for the treatment of genital herpes. One of the characteristics why Acyclovir has become one of the most commonly used as well as effective drug is that it inhibits low toxic properties, and acts as a resistance agent even after long duration of usage.
Another important chemical property associated with Acyclovir is that during the course of its activity against the virus such as genital herpes, the drug convincingly covers more than one affected area. In addition, the drug also acts to eliminate the growing chain of DNA’s, that have a tendency of replicating or reproducing virus, thus its activity as a “prodrug” as well.
A brief on the extremely low toxicity levels found from the usage of Acyclovir reveals that the chemistry of the drug is actually “inactivate unless it is phosphorylated. This pre-condition or pre-requisite of the Acyclovir drug is mediated by the herpes virus enzyme Thymidine Kinase, something, which is, absent in the host cells. Due to this particular property, non-infected cells are only exposed to the inactive, non-toxic, non-phosphorylated Acyclovir.
In spite of the immense popularity and safety of the Acyclovir drug, it does suffer from a drawback, one that disallows the drug to easily absorb with the plasma of the patient. Thus, it has been found that only 15 to 20 percent of the patients who were given the drug orally showed positive results as far as the absorption with the blood factor was involved. In turn, this necessitated the need for larger and continuous forms of drug therapy, which is not expensive for the average patient, the duration too may become a problem.